LotaV3, Main, Exploration, bibRecord, 000113

Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells

Identifieur interne : 000113 ( Main/Exploration ); précédent : 000112; suivant : 000114

Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells

Auteurs : Cristian Do As [Chili] ; Macarena Fritz [Chili] ; Valeria Manríquez [Chili] ; Gabriela Tej N [Chili] ; María Rosa Bono [Chili] ; Alejandra Loyola [Chili] ; Mario Rosemblatt [Chili]

Source :

Clinical and Developmental Immunology [ 1740-2522 ] ; 2013.

RBID : PMC:3662173

Abstract

Regulatory T cells are a specific subset of lymphocytes that suppress immune responses and play a crucial role in the maintenance of self-tolerance. They can be generated in the thymus as well as in the periphery through differentiation of naïve CD4⁺ T cells. The forkhead box P3 transcription factor (Foxp3) is a crucial molecule regulating the generation and function of Tregs. Here we show that the foxp3 gene promoter becomes hyperacetylated in in vitro differentiated Tregs compared to naïve CD4⁺ T cells. We also show that the histone deacetylase inhibitor TSA stimulated the in vitro differentiation of naïve CD4⁺ T cells into Tregs and that this induction was accompanied by a global increase in histone H3 acetylation. Importantly, we also demonstrated that Tregs generated in the presence of TSA have phenotypical and functional differences from the Tregs generated in the absence of TSA. Thus, TSA-generated Tregs showed increased suppressive activities, which could potentially be explained by a mechanism involving the ectonucleotidases CD39 and CD73. Our data show that TSA could potentially be used to enhance the differentiation and suppressive function of CD4⁺Foxp3⁺ Treg cells.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662173

DOI: 10.1155/2013/679804
PubMed: 23737814
PubMed Central: 3662173

Affiliations:

Chili

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Regulatory T cells are a specific subset of lymphocytes that suppress immune responses and play a crucial role in the maintenance of self-tolerance. They can be generated in the thymus as well as in the periphery through differentiation of naïve CD4<sup>+</sup>
 T cells. The forkhead box P3 transcription factor (Foxp3) is a crucial molecule regulating the generation and function of Tregs. Here we show that the <italic>foxp3</italic>
 gene promoter becomes hyperacetylated in <italic>in vitro</italic>
 differentiated Tregs compared to naïve CD4<sup>+</sup>
 T cells. We also show that the histone deacetylase inhibitor TSA stimulated the <italic>in vitro</italic>
 differentiation of naïve CD4<sup>+</sup>
 T cells into Tregs and that this induction was accompanied by a global increase in histone H3 acetylation. Importantly, we also demonstrated that Tregs generated in the presence of TSA have phenotypical and functional differences from the Tregs generated in the absence of TSA. Thus, TSA-generated Tregs showed increased suppressive activities, which could potentially be explained by a mechanism involving the ectonucleotidases CD39 and CD73. Our data show that TSA could potentially be used to enhance the differentiation and suppressive function of CD4<sup>+</sup>
Foxp3<sup>+</sup>
 Treg cells.</p>
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<name sortKey="Fritz, Macarena" sort="Fritz, Macarena" uniqKey="Fritz M" first="Macarena" last="Fritz">Macarena Fritz</name>
<name sortKey="Fritz, Macarena" sort="Fritz, Macarena" uniqKey="Fritz M" first="Macarena" last="Fritz">Macarena Fritz</name>
<name sortKey="Loyola, Alejandra" sort="Loyola, Alejandra" uniqKey="Loyola A" first="Alejandra" last="Loyola">Alejandra Loyola</name>
<name sortKey="Loyola, Alejandra" sort="Loyola, Alejandra" uniqKey="Loyola A" first="Alejandra" last="Loyola">Alejandra Loyola</name>
<name sortKey="Manriquez, Valeria" sort="Manriquez, Valeria" uniqKey="Manriquez V" first="Valeria" last="Manríquez">Valeria Manríquez</name>
<name sortKey="Rosemblatt, Mario" sort="Rosemblatt, Mario" uniqKey="Rosemblatt M" first="Mario" last="Rosemblatt">Mario Rosemblatt</name>
<name sortKey="Rosemblatt, Mario" sort="Rosemblatt, Mario" uniqKey="Rosemblatt M" first="Mario" last="Rosemblatt">Mario Rosemblatt</name>
<name sortKey="Rosemblatt, Mario" sort="Rosemblatt, Mario" uniqKey="Rosemblatt M" first="Mario" last="Rosemblatt">Mario Rosemblatt</name>
<name sortKey="Tej N, Gabriela" sort="Tej N, Gabriela" uniqKey="Tej N G" first="Gabriela" last="Tej N">Gabriela Tej N</name>
</country>
</tree>
</affiliations>
</record>

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{{Explor lien
   |wiki=    Eau
   |area=    LotaV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3662173
   |texte=   Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells
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Serveur d'exploration Lota lota

Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells

Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells

Source :

Abstract

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	Serveur d'exploration Lota lota
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